Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions
نویسندگان
چکیده
منابع مشابه
Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions.
Apoptosis is a metazoan process of controlled cell elimination that plays critical roles in embryonic development and adult tissue homeostasis. Apoptosis dysregulation contributes to several important diseases, including cancer. Two distinct yet interconnected signaling pathways control apoptosis by activating a core intracellular machinery of death proteases called caspases. The intrinsic apop...
متن کاملAnthrax Bioterrorism: Lessons Learned and Future Directions
n September 11, 2001, the United States experienced the worst terrorist attack in its history. As the nation sought to deal with this tragedy, it would face a second wave of terrorism—this time, in the form of a biological attack. The suspicion of anthrax in a patient by an astute infectious disease clinician along with capable clinical and public health laboratory staff in Florida would lead t...
متن کاملPediatric resuscitation: lessons learned and future directions.
The science of resuscitation has had significant and meaningful advances over the past fifty years, with resultant improvements in outcomes for both adult and pediatric populations. This article aims to describe some of the recent advances in pediatric resuscitation, including aspects of care affecting the management of cardiac arrest and sepsis, and to give a glimpse into technologies and meth...
متن کاملVentilation: Lessons Learned and Future Directions
Mechanical ventilation practices continue to evolve. In particular, the ventilatory care of patients with acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) has been refocused on avoiding or minimizing further damage to the fragile, injured lung. Conventional ventilators have been used successfully to limit this ventilator-induced lung injury (VILI) (1–3), but questions rema...
متن کاملSevere Asthma in Children: Lessons Learned and Future Directions.
Severe asthma in children is a complicated and heterogeneous disorder that is extremely challenging to treat. Although most children with asthma derive clinical benefit from daily administration of low-to-medium-dose inhaled corticosteroid (ICS) therapy, a small subset of children with "severe" or "refractory" asthma require high doses of ICS and even systemic corticosteroids to maintain sympto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2015
ISSN: 0021-9738
DOI: 10.1172/jci80420